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Cellular and Molecular Basis of Systems
and Integrative Biology:

Training Faculty

PHYSIOLOGY

Jimo Borjigin
Investigating the properties of the central pacemaker by studying the melatonin output, the hands of the circadian clock under normal and perturbed conditions.

Susan Brooks
Single skeletal muscle fiber mechanics; role of contraction-induced muscle injury in the changes that occur in skeletal muscle structure and function with aging and in the pathogenesis of muscular dystrophy.

Frank Brosius
Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and metabolism in the pathogenesis of vascular changes in hypertension.

Christin Carter-Su
Signalling pathways used by cytokine receptors and JAK tyrosine kinases; molecular actions of growth hormone; role of SH2-B adaptor proteins in regulation of the cytoskeleton and nerve cell differentiation and survival.

Louis D'Alecy
Mechanisms of gender-based differences in ischemic tolerance; cardiorespiratory function in transgenic mice by telemetry techniques; adaption to acute hypoxia (high altitude); endogenous inhibitors of nitric oxide synthase in ischemia, multiorgan failure; therapeutic protection of the brain, spinal cord, and kidney.

John A. Faulkner
Muscle mechanics and mechanisms involved in injury, degeneration, and regeneration of skeletal muscle fibers.

Gary Hammer
Molecular mechanisms of adrenal growth and differentiation, focusing on the molecular cascades involving nuclear receptors and transcriptional cofactors which initiate adrenal-specific transcriptional programs necessary for proper initiation of adrenal formation in mice and humans.

Marc Hershenson


Bret Hughes
Structure, function, and regulation of ion channels in the retinal pigment epithelium.

Fred J. Karsch
Neuroendocrine control of ovarian cyclicity, seasonal breeding, and immune-neuro-endocrine interactions.

P. Landis Keyes
Hormonal regulation of cell diferentiation and steroidogenesis in the ovary; role of immune cells in ovarian function.

Anatoli Lopatin
Regulation of potassium channels by polyamines.

Ralph Lydic
Transmembrane cell signaling; integrative aspects of respiratory and arousal state control.

Ormond MacDougald
Adipocyte gene expression and metabolism; transcriptional and post-translational regulation of the transcription factor C/EBPa.

Juanita Merchant
Molecular mechanisms of gastric epithelial cell growth.

Joseph Metzger
Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart.

Martin Meyers
The biology of growth factor receptors relevant to diabetes and obesity and the mechanisms by which they control basic cellular processes and metabolism.


Richard Mortensen
Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways.

Mark Opp
Stressor-induced alterations in arousal state.

Vasantha Padmanabhan


Gina Poe
Basic sleep processes, development, learning and memory, and optimization of cognitive performance

Liangyou Rui
Mechanisms of obesity and type 2 diabetes, investigating the molecular mechanisms by which the hypothalamus senses and integrates metabolic and neuroendocrine signals to regulate energy homeostasis.

Linda C. Samuelson
Function of gut/brain peptides in the mouse; mouse developmental genetics; generation of mouse mutants by homologous recombinant in embryonic stem cells.

Jessica Schwartz
Cellular and molecular mechanisms of growth hormone and growth factor action; regulation of gene expression.

Gary Smith
Mammalian gamete and embryo developmental biology.

Edward Stuenkel
Molecular and cellular regulation of neurotransmitter and neurohormone secretion.

Margaret Westfall
Thin filament regulation of contractile function; cellular and molecular dissection of contractile function using viral-based gene transfer into cardiac myocytes.

John A. Williams
Calcium as an intracellular messenger; cellular mechanisms of pancreatic secretion.

BIOCHEMISTRY

Michael D. Uhler
Molecular genetic studies of the regulation of cellular physiology by protein phosphorylation.

HUMAN GENETICS

Sally Camper
Development and function of the neuroendocrine system using transgenic mice, gene targeting, and molecular genetic analysis of mouse mutations.

Miriam Meisler
Isolation of genes responsible for neuromuscular and inner ear disorders in mouse and human.

Diane Robins
Hormonally regulated gene transcription and androgen receptor function at levels from the molecular to the organismal; mouse models of development and oncogenesis.

PHARMACOLOGY

Ronald Holz
The molecular mechanisms underlying secretion of prepackaged hormones and neurotransmitters.

Lori Isom
Structure and function of voltage-gated sodium channels; role of
voltage-gated sodium channels in epilepsy, arrhythmia, and
demyelinating disease.


Richard Neubig
Mechanism of alpha-adrenergic receptors.

PATHOLOGY

Paul Killen
The hypertoncity stress response: Signal transduction and transcriptional activation of hypertonicty stress response genes such as aldose reductase and the sodium-dependent myoinositol cotransporter.

Steven Kunkel
Cellular and molecular regulation of cytokine release.

NEUROSCIENCE

Huda Akil
Regulation and function of opioid and related peptides.

Audrey Seasholz
Molecular regulation of stress and anxiety; regulation of corticotropin-releasing hormone (CRH) and CRH-binding protein expression.

Stanley Watson
Molecular neurobiology of opioid and neuroactive peptide systems.

INTERNAL MEDICINE

Roger Wiggins
Biology of glomerular crescent formation: mechanisms by which the glomerulus responds to immunological attack and develops glomerulosclerosis.

CELL & DEVELOPMENTAL BIOLOGY

Michael Welsh
Expression and function of heat-shock proteins, particularly hsp27, in cell response to toxicants in spermatogenesis and during embryogenesis.

PUBLIC HEALTH

Rita Loch-Caruso
Mechanisms of abnormal parturition with an emphasis on toxicant alteration of uterine smooth muscle cell and tissue functions.

BIOLOGY

Douglas Foster
Neuroendocrinology of sexual differentiation and sexual maturation.