|
Hormone Action & Signal
Transduction
Larry Argetsinger, Ph.D. (University of Michigan, 1991) Mechanisms
by which the cytokines which activate the tyrosine kinase Jak2 activate
distinct sets of signaling pathways; mapping the phosphorylation
sites in proteins.
Christin Carter-Su, Ph.D. (University
of Rochester, 1978) Signalling pathways used by cytokine receptors
and JAK tyrosine kinases; molecular actions of growth hormone; role
of SH2-B adaptor proteins in regulation of the cytoskeleton, nerve
cell differentiation and survival.
Gary
Hammer, M.D., Ph.D. (Tufts, 1992) The mechanisms by which signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on the dysregulated growth of adrenocortical stem cells in development and cancer.
Allen Hsu, Ph.D. (University of Kentucky) Genetics and cell biology of aging using C. elegans as a model organism.
Ormond A. MacDougald, Ph.D. (Michigan State University, 1992) Adipocyte gene expression and metabolism; transcriptional and post-translational regulation of the transcription factor C/EBPa.
Ram Menon, M.D. Understanding the role of the growth hormone (GH)/ growth hormone receptor (GHR) axis in health and disease.
Richard Mortensen, M.D., Ph.D.
(Cornell, 1983, Rockefeller, 1984) Molecular signal transduction
pathways important in cardiovascular risk and disease. Pathways
in hypertension and diabetes. G-proteins, PPARs, growth pathways.
Martin Myers, M.D., Ph.D. (Harvard, 1997) Signaling pathways activated by Leptin receptor and Jak2; mechanisms of
feedback inhibition of leptin receptor/Jak2 signaling; role of leptin
signals in mammalian energy homeostasis, neuroendocrine function, immune
function, and neuronal development.
Liangyou Rui, Ph.D. (Michigan,
1998) Cell signaling; molecular mechanisms of obesity and type 2
diabetes
Alan
Saltiel, Ph.D. (North Carolina, 1980) Mechanisms of action for
hormones, and growth factors; second messengers and protein phosphorylation;
molecular mechanisms of diabetes.
Jessica Schwartz, Ph.D. (Harvard,
1974) Cellular and molecular mechanisms of growth factor action;
regulation of gene expression.
Matthew J. Wishart, Ph.D. (University of Michigan, 2000)
Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase
adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian
reproduction.
top
Rhythms & Reproductive Cycles
Jimo Borjigin, Ph.D. (Johns Hopkins, 1994) Mechanisms of circadian pacemaker reentrainment; molecular regulation of pineal circadian rhythms; role of PINA (Pineal Night-specific ATPase) in circadian rhythms and Wilson disease.
Fred J. Karsch, Ph.D. (Illinois,
1970) Neuroendocrine control of ovarian cyclicity, seasonal breeding,
and immune-neuro-endocrine interactions.
Vasantha Padmanabhan, Ph.D. (Indian Insitutute of Science) Translational and centers on understanding the fetal origin of pubertal and adult reproductive and metabolic disorders and the impact of steroids and estrogenic environmental pollutants in programming such defects.
Gary Smith, Ph.D. (Washington
State, 1993) Mammalian gamete and embryo developmental biology.
top
Gastrointestinal
Physiology
Xuequn Chen, Ph.D. (Michigan, 2003) Proteomics analysis of secretory pathway mainly in exocrine pancreas; molecular mechanisms of membrane trafficking and regulated exocytosis in pancreatic acinar cells.
Juanita L. Merchant, M.D., Ph.D. (Yale, 1984) Molecular mechanisms of gastric epithelial cell growth.
Linda C. Samuelson, Ph.D. (Chicago, 1984) Function of gastrointestinal peptides in the mouse; regulation of stomach acid secretion and parietal cell function; mechanisms of epithelial cell development in the gastrointestinal tract; transgenic and knockout mice.
John A. Williams, M.D., Ph.D. (Washington (Seattle), 1968) Calcium as an intracellular messenger; cellular mechanisms of pancreatic secretion; regulation of pancreatic growth.
top
Cardiovascular
& Hypertension
David Bohr, M.D. (Michigan, 1942)
Mechanisms responsible for hypertension.
Steven L. Britton, Ph.D. Aerobic capacity is the major determinant of the continuum between health and disease.
Louis G. D'Alecy, D.M.D., Ph.D.
(Pennsylvania, 1971) Mechanisms of gender-based differences in ischemic
tolerance; cardiorespiratory function in transgenic mice by telemetry
techniques; adaption to acute hypoxia (high altitude); endogenous
inhibitors of nitric oxide synthase in ischemia, multiorgan failure;
therapeutic protection of the brain, spinal cord, and kidney.
Todd Herron, Ph.D. (Missouri, 2002) Molecular mechanisms of inherited and acquired forms of cardiomyopathy associated with alterations of cardiac myosin, the heart's molecular motor. Thick filament based regulation of cardiac myofilament and cellular function. Gene delivery of fast molecular motors to the failing heart.
Warren E. Lockette, M.D. (Michigan,
1981) Molecular genetics of human hypertension and diabetes mellitus;
ethnic differences in acid excretion and bone mineralization; cardiovascular
adaption to exercise training.
Richard Keep, Ph.D. (Aberdeen, UK, 1984) Blood-brain and blood-cerebrospinal fluid barrier physiology; brain injury following cerebral ischemia and cerebral hemorrhage; obesity and the genesis of hypertension.
Joseph M. Metzger, Ph.D. (Marquette, 1985) Molecular and Systems Biology of the Heart; Cardiac transgenesis; Molecular mechanisms of contraction in skeletal and cardiac muscle; Experimental gene therapy for the failing heart.
Daniel E. Michele, Ph.D. (Michigan,
2000) Molecular mechanisms of human cardiomyopathies and skeletal
myopathies, with a focus on muscular dystrophy, using mouse models.
Extracellular matrix receptors in central nervous system development
and muscle disease.
DeWayne Townsend, D.V.M, Ph.D. (Minnesota, 2003) Understanding the pathophysiology of dystrophic cardiomyopathy and translating this knowledge into new therapies. The role of the signaling and structural functions of dystrophin in heart disease. Implementing exogenous membrane sealants for the treatment of muscular dystrophy.
Margaret
Westfall, Ph.D. (Loyola, 1989) Thin filament regulation of contractile
function; cellular and molecular dissection of contractile function
using viral-based gene transfer into cardiac myocytes.
top
Renal & Pulmonary
Function
Frank Brosius, M.D. (Kansas, 1979) Pathways by which glucose
transporter expression affects cell death and the pathogenesis of
diabetic nephropathy; abnormalities of glucose transport and metabolism
in the pathogenesis of vascular changes in hypertension.
Marc B. Hershenson, M.D. (Illinois, 1981) Cellular and molecular mechanisms underlying chronic airways diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis and bronchopulmonary dysplasia.
top
Muscle
Contractile Mechanisms
Susan V. Brooks, Ph.D (Michigan, 1992) Mechanical properties of whole skeletal muscles and single muscle fibers, primarily as related to the effects of aging, injury, unloading, and muscular dystrophy on skeletal muscle structure and function.
John A. Faulkner, Ph.D. (Michigan,
1962) Muscle mechanics and mechanisms involved in injury, degeneration,
and regeneration of skeletal muscle fibers.
Lisa Larkin, Ph.D. (UC Davis) The purpose of our research is to design, fabricate, and evaluate the structural and contractile characteristics of three-dimensional (3-D) engineered tissues containing myotendinous junctions and neuromuscular junctions for use in basic studies of muscle development and repair of complex tissues following traumatic injuries.
top
Channels
& Membrane Function
Bret
A. Hughes, Ph.D. (Berkeley, 1983) Structure, function, and regulation
of ion channels in the retinal pigment epithelium.
Anatoli N. Lopatin, Ph.D. (Moscow,
Russia, 1990) Regulation of potassium channels by polyamines.
James Offord, Ph.D. (University
of Iowa, 1986) Molecular biological techniques to understand structure
and function of voltage sensitive calcium channels and inward rectifier
potassium channels.
Donald G. Puro, M.D., Ph.D. (Rochester, 1975) Physiology of
ion channels in retinal glial and vascular cells.
top
Neurophysiology
Robert Bradley, Ph.D. (Florida
State, 1970) Neurophysiology of the taste system.
Ralph
Lydic, Ph.D. (Texas Tech, 1979) Transmembrane cell signaling; integrative aspects of respiratory and arousal state control.
John S. McReynolds, M.D. (Harvard,
1965) Neurophysiology of the retina.
Thomas Morrow,
Ph.D. (Michigan, 1976) Neurobehavioral mechanisms of pain and
somatic sensation.
Goeffrey G.
Murphy, Ph.D. (UCLA, 1998) Neurobiological substrates of learning and memory.
Mark
Opp, Ph.D. (Washington State, 1987) Stressor-induced alterations
in arousal state.
Gina Poe, Ph.D. (University of
California, Los Angeles, 1995) Basic sleep processes, development,
learning and memory, and optimization of cognitive performance.
Susan Shore, Ph.D. (Univ. Witwatersrand, 1975; Louisiana State University Medical School 1981). Anatomy and physiology of efferent pathways to the cochlear nucleus; somatosensory-auditory interactions; vesicular glutamate transporters, sensory system neurotransmitters.
Edward L. Stuenkel, Ph.D. (Hawaii,
1983) Molecular and cellular regulation of neurotransmitter and
neurohormone secretion.
Michael Sutton, Ph.D. (Yale) Local control of dendritic protein synthesis, synaptic plasticity, and memory.
Michael Wang, M.D., Ph.D. (Johns Hopkins, 1994) Molecular basis or endogenous factors which improve outcome from neuronal injury with an emphasis on stroke. Two main areas of interest include: 1) signaling mechanisms within neurons triggered by estrogen, and 2) neuronal genes induced by bone morphogenetic proteins.
X.Z. Shawn Xu, Ph.D. (Johns Hopkins 2000) 1) Neuronal signaling, behavior and drug addiction in the genetic model organism C. elegans. 2) Calcium signaling.
top
|
