Current Research
We have been investigating signal transduction in insulin action, focusing on understanding the molecular mechanisms underlying the specificity of this important hormone. One important clue may lie in the compartmentalization of signaling events, both regarding signal initiation from the insulin receptor, as well as signal reception in different cellular domains. Studies include evaluation of plasma membrane microdomains called caveolae in insulin action, small G proteins mediating activation of glucose transport, molecular scaffolds critical to the regulation of protein phosphorylation and dephosphorylation, and regulation of vesicle trafficking in fat and muscle cells.
Representative Publications:
Ribon, V., Printen, J.A., Hoffman, N.G., Kay, B.K. and Saltiel, A.R. "A novel, Multifunctional c-Cbl Binding Protein in Insulin Receptor Signaling in 3T3-L1 Adipocytes." Mol. Cell. Biol., 18:872, 1998.
Ribon, V., Herrera, R., Kay, B.K. and Saltiel, A.R. "A Role for CAP, a Novel Multifunctional SH3 Domain-Containing Protein in Formation of Actin Stress Fibers and Focal Adhesions." J. Biol. Chem., 273:4073, 1998.
Brady, M.J., Bourbonais, F.J. and Saltiel, A.R. "The Activation of Glycogen Synthase by Insulin Switches from Kinase Inhibition to Phosphatase Activation During Adipogenesis in 3T3-L1 Cells." J. Biol. Chem., 273:14063, 1998.
Kao, A.W., Noda, Y., Johnson, J.H., Pessin, J.E. and Saltiel, A.R. "Fructose 1,6 Bisphosphate Aldolase Mediates the Association of F-Actin with the Insulin Responsive (GLUT4) Glucose Transporter." J. Biol. Chem., 274:17742, 1999.
Min, J., Okada, S., Coker, K., Ceresa, B.P., Elmendorf, J.S., Syu, L-J, Noda, Y., Saltiel, A.R. and Pessin, J.E. "Synip: A Novel Insulin-Regulated Syntaxin 4 Binding Protein Mediating Glut4 Translocation in Adipocytes." Molecular Cell, 3:751, 1999.
Ribon, V., Johnson, J.H., Camp, H.S. and Saltiel, A.R. "Thiazolidinediones and Insulin Resistance: PPARg Activation Stimulates Expression of the CAP Gene." Proc. Natl. Acad. Sci. USA, 95:14751, 1998.
Sebolt-Leopold, J.S., Dudley, D.T., Herrera, R., Van Beccelaere, K., Wiland, A., Gowan, R.C., Tecle, H., Barrett, S.D., Bridges, A., Przybranowski, S., Leopold, W.R. and Saltiel, A.R. "Blockade of the MAP Kinase Pathway Suppresses Growth of Colon Tumors In Vivo." Nature Medicine, 5:810, 1999.
Syu, L-J and Saltiel, A.R. "Lipotransin, a Novel Docking Protein for Hormone Sensitive Lipase." Molecular Cell 4, 109, 1999.
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