Renu Jain, Ph.D. ~Research Investigator Ph.D., Biochemistry Osmania University Hyderabad, India, 1997. Mentor: Dr. LINDA SAMUELSON 7761 Med Sci II 734-647-2118 renujain@umich.edu

Current Research:

Food intake and digestion are the most fundamental and necessary processes to all vertebrates with stomach being one of the major organ involved in digestion. We at Samuelson's laboratory are interested in examining the regulation of stomach acid secretion and the mechanisms involved in the maturation of the acid-secreting parietal cells. Currently, we are focusing on the study of differential gene expression in the gastrin-deficient mouse model.

Representative Publications:

Characterization of constitutive protein secretion in PC12 cells that lack the regulated secretory pathway. Annals NY Acad. Sci. in press, 2002. [Gorr S-U and Jain RK].

Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells. In press, Biochemical Journal, 2001. [Renu K. Jain, Paul B.M. Joyce, Miguel Molinete, Philippe A. Halban and Sven-Ulrik Gorr].

Comparative sorting of neuroendocrine secretory proteins: The search for common ground in a mosaic of sorting models and mechanisms. Mol. Cell. Endo., 2001, 172, 1-6. [Sven-Ulrik Gorr, Renu K. Jain, Ulrike-Kuehn, Paul B.M. Joyce and Darrin Cowley].

Aggregation chaperones enhance aggregation and storage of secretory proteins
in endocrine cells. J. Biol. Chem., 2000, 275, 27032-27036. [Renu K. Jain, Paul B.M. Joyce and Sven-Ulrik Gorr].

Trafficking of non-regulated secretory proteins in insulin secreting (INS-1) cells. Diabetelogia, 2000, 43, 1157-1164. [M. Molinete, V. Lilla, R. Jain, P. Joyce, S-U. Gorr, M. Ravazzola and P. A. Halban].

Neurotoxic potential of three structural analogs of a,ß-N-oxalyl-L-diaminopropionic acid ( ODAP ) [I.A. Omelchenko, Renu K.Jain, M.A.Junaid, S.L.N.Rao and Charles N.Allen] Neurochemical research, 1999, June,24(6)791-797.

Receptor interactions of a, ß-N-oxalyl-L-diaminopropionic acid, the Lathyrus sativus putative excitotoxin with synaptic membranes [Renu K. Jain, M.A.Junaid and S.L.N.Rao] Neurochemical research, 23, 9, 1998,1193-1198.

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