Hylan C. Moises, Ph.D. Professor of Physiology B.S., University of Washington, 1971 Ph.D., University of Rochester, 1979 7789 Med. Sci. II (734) 763-9450 moises@umich.edu

Current Research:  

Research in my laboratory focuses on the cellular and molecular mechanisms that underlie ion channel regulation by opioid and other G protein-coupled receptors and the physiological importance of this channel modulation in neuronal excitability, synaptic transmission and plasticity. Current research focuses on the characterization of opioid receptor coupling to voltage-sensitive calcium channels, how this relates to receptor-mediated inhibitory control of neurotransmitter release, and identification of the molecular events that maintain specificity of receptor-effector interactions, in addition to those that account for tolerance and desensitization. These types of questions are being addressed by combining patch clamp recordings in isolated neurons, nuerosecretory terminals or brain slice preparations with time-resolved membrane capacitance measurements and fluorescent imaging techniques. A second direction of our research is aimed at characterizing the identity, synaptic relationships and cellular actions of the neurotransmitters and neuroactive peptides that mediate signaling in hypothalamic and brainstem circuitry involved in appetite regulation, energy homeostasis and reflex control of gastrointestinal function.

Representative Publications:

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