Faculty Profiles

 

Current Research:
I am an endocrinologist and physiologist whose laboratory performs basic science and clinical, translational research:

 

1) Vascular reactivity of hypertension.

 

2) Molecular genetics of complex quantitative traits in minority populations

 

3) Human performance in extreme environments

 

For our basic science studies, we utilize: the isolated muscle bath, cell cultures and cell suspensions of vascular smooth muscle and endothelial cells; microfluorometric assays with intracellular probes, radioimmunoassay; RT PCR of mRNA transcripts; and library screening with cDNA probes. For our clinical studies, we study adrenergic receptor and thiazide receptor function with a variety of in vivo techniques

 

Representative Publications:
Wisbach G, Tobias S, Woodman R, Spalding A, Lockette W. Preserving cardiac output with beta-adrenergic receptor blockade and inhibiting the Bezold-Jarisch reflex during resuscitation from hemorrhage. J Trauma, 2007, 63(1):26-32.

 

Fox WC, Watson R, Lockette W. Acute hypoxemia increases cardiovascular baroreceptor sensitivity in humans. Am J Hypertension, 2006, 19(9):958-63

 

Finley JC, O’Leary MJ, Wester D, MacKenzie S, Shepard N, Farrow S, Lockette W. A genetic polymorphism of the alpha-2 adrenergic receptor increases autonomic responses to stress. J Appl Physiol, 2004, 96:2231-2239

 

Fox WC, Hall C, Hall E, Lockette W. Cardiovascular baroreceptors mediate susceptibility to hypothermia in man. Aviat Space Environ Med 2003, 74:132-137

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