Warren Lockette, M.D. ~Adjunct Associate Professor of Physiology M.D., University of Michigan, 1981 John Dingell V.A. Hospital, Detroit (734) 641-6546 ridiculo@umich.edu

Current Research:

My laboratory is interested in basic science and clinical research:

• Vascular reactivity of hypertension. We are interested in the role of the endothelium, cyclic nucleotides, the phosphatidyl-inositol pathway, the regulation of intracellular calcium and pH on gene expression in the control of vascular tone.
• Cardiovascular regulation during space flight. We are interested in determinants of Coriolis stress susceptibility and the roles of the alpha-2 adrenergic receptor and atrial peptides in controlling fluid shifts and changes in capillary permeability during space flight.

For our basic science studies, we utilize: the isolated muscle bath, cell cultures and cell suspensions of vascular smooth muscle and endothelial cells, microfluorometric assays with intracellular probes, and radioimmunoassay, Northern analysis of mRNA transcripts, and library screening for cDNA probes. For our clinical studies, we use Coriolis stress testing and the technique of lower body negative pressure with plethysmography.

Representative Publications:

Finley JC, O'Leary MJ, Wester D, MacKenzie S, Shepard N, Farrow S, Lockette W. A genetic polymorphism of the alpha-2 adrenergic receptor increases autonomic responses to stress. J Appl Physiol, 2004, 96:2231-2239

Fox WC, Hall C, Hall E, Lockette W. Cardiovascular baroreceptors mediate
susceptibility to hypothermia in man. Aviat Space Environ Med 74:132-137, 2003

Vaitkevicius, H, Turner I, Spalding A, Lockette W.  Chloride increases
adrenergic receptor-mediated platelet and vascular responses. Am J Hypertension
15(6):492-498, 2002

Ethnic differences in titratable acid excretion and bone mineralization. Med Sci
Sports Exercise 34(2):295-302, 2002

MacKenzie S, Vaitkevicius H, Lockette W. Sequencing and characterization of the
human thiazide-sensitive Na/Cl cotransporter gene promoter. Biochem Biophys Res
Commun 282(4):991-1000, 2001

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