Faculty Profiles
Current Research:
1) Vascular reactivity of hypertension.
2) Molecular genetics of complex quantitative traits in minority populations
3) Human performance in extreme environments
For our basic science studies, we utilize: the isolated muscle bath, cell cultures and cell suspensions of vascular smooth muscle and endothelial cells; microfluorometric assays with intracellular probes, radioimmunoassay; RT PCR of mRNA transcripts; and library screening with cDNA probes. For our clinical studies, we study adrenergic receptor and thiazide receptor function with a variety of in vivo techniques Representative Publications: Wisbach G, Tobias S, Woodman R, Spalding A, Lockette W. Preserving cardiac output with beta-adrenergic receptor blockade and inhibiting the Bezold-Jarisch reflex during resuscitation from hemorrhage. J Trauma, 2007, 63(1):26-32. Fox WC, Watson R, Lockette W. Acute hypoxemia increases cardiovascular baroreceptor sensitivity in humans. Am J Hypertension, 2006, 19(9):958-63
Finley JC, O’Leary MJ, Wester D, MacKenzie S, Shepard N, Farrow S, Lockette W. A genetic polymorphism of the alpha-2 adrenergic receptor increases autonomic responses to stress. J Appl Physiol, 2004, 96:2231-2239 Fox WC, Hall C, Hall E, Lockette W. Cardiovascular baroreceptors mediate susceptibility to hypothermia in man. Aviat Space Environ Med 2003, 74:132-137 Contact Us | Department Area (password) | University of Michigan | UM Medical School | Integrative Genomics © U-M Molecular & Integrative Physiology. study of the functions of living organisms. All rights reserved. |