Louis G. D'Alecy, D.M.D., Ph.D. ~Professor of Physiology D.M.D., Ph.D. University of Pennsylvania, 1971 7708 Med Sci II (734) 763-2566 lgdalecy@umich.edu

Current Research:

My research interest is hypothesis testing in the area of normal and pathologic control and regulation of the cardiovascular system. A wide range of experimental approaches is used to evaluate the functional consequences of reduced blood flow and oxygen availability. Preventive and therapeutic interventions are pursued as well as basic mechanisms of cell damage. Whole animal studies using either anesthetized or conscious preparations are complemented by in vitro preparations, where appropriate, to test physiologically important hypotheses. Systemic hypoxia, regional ischemia and cardiac arrest/resuscitation models, in mice, rats and dogs are used sequentially and simultaneously to acquire data relevant to the resolution of clinical problems. Undergraduate, graduate( see Jin publications below) , medical, and postdoctoral (see Zwemer publications below) participation is encouraged at all levels of laboratory activity. 


Representative Publications:

Gomez CA, Crowley DC, D'Alecy L, Goldberg CS, Charpie JR. Effect of arginine on cyclosporine-induced systemic hypertension after cardiac transplantation in the young. Am J of Cardiology. 87(7):927-933, 2001

Knipp BS, Peterson DA, Rajagopalan S, Kehrer C, Ford JW, D'Alecy LG, Whitesall SE, Eagleton MJ, Wakefield TW, Henke PK, Jacobs LA, MD, Greenfield LJ, Stanley JC, and Upchurch GR. Impaired Vasoreactivity Despite an Increase in Plasma Nitric Oxide in Patients with Abdominal Aortic Aneurysms, J Vas Surg 35:363-367, 2002

Rajagopalan S, Pfenninger D, Chakrabarti A, Kehrer C, Somers E, Pavlic R, McCune W, Mukherjee D, Brook R, D'Alecy LG, Kaplan M. Increased ADMA and endothelin 1 levels in secondary Raynaud's Syndrome: “Implications for vascular dysfunction and progression of disease”. Arthritis & Rheum 48: 1992-2000, 2003

Sans MD, DiMagno MJ, D'Alecy LG and Williams JA. Caerulein-induced acute pancreatitis inhibits protein synthesis in mouse pancreas through effects on eukaryotic initiation factor 2B and 4F. Am J Physiol Gastrointest Liver Physiol 285: G517-528, 2003.

Saran R, Novak JE, Desai A, Abdulhayoglu E, Warren JS, Bustami R, Handelman GJ, Barbato D, Weitzel W, D'Alecy LG, and Rajagopalan S. Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study. Nephrol Dial Transplant 18: 2415-2420, 2003.

Dvonch JT, Brook RD, Keeler GJ, Rajagopalan S, D’Alecy L.G, Marsik FJ, Morishita M, Yip FY, Brook JR, Wagner J, and Harkema JR. (2004) Effects of Concentrated Fine Ambient Particles on Rat Plasma Levels of Asymmetric Dimethylarginine. Inhalation Toxicology, xxxxxxxxxxxx In Press 2004.

Zambricki EA, D'Alecy LG. Rat sex differences in anesthesia. Comparative Medicine 54(1):49-53, 2004

Whitesall SE, Hoff JB, Vollmer AP and D'Alecy LG. Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods. . Am J Physiol Heart Circ Physiol 286:H2408-H2415, 2004

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