Faculty Profiles

 

Current Research:

My research interest is hypothesis testing in the area of normal and pathologic control and regulation of the cardiovascular system. A wide range of experimental approaches is used to evaluate the functional consequences of reduced blood flow and oxygen availability. Preventive and therapeutic interventions are pursued as well as basic mechanisms of cell damage. Whole animal studies using either anesthetized or conscious preparations are complemented by in vitro preparations, where appropriate, to test physiologically important hypotheses. Systemic hypoxia, regional ischemia and cardiac arrest/resuscitation models, in mice, rats and dogs are used sequentially and simultaneously to acquire data relevant to the resolution of clinical problems. Undergraduate, graduate, medical, and postdoctoral participation is encouraged at all levels of laboratory activity.

 

Representative Publications:

Zwemer CF, Song MY, Carello KA and D'Alecy LG.  Strain differences in response to acute hypoxia: CD-1 versus C57BL/6J mice.  J Appl Physiol 102:286-293, 2007.
        
Song MY, Zwemer CF, Whitesall SE, and D'Alecy LG.  Nitric oxide synthase inhibition increases acute hypoxic tolerance in mice.  J Appl Physiol 102:610-615,2007.

 

Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Mortensen RM.  Direct monitoring pressure overload predicts cardiac hypertrophy in mice. Physiol Meas 2007; 28(11): 1329‑1339.

 

Fomicheva E, Turner I, Edwards TG, Hoff J, Arden E, D’Alecy LG and Metzger JM. Double oxygen sensing vector system for robust hypoxia/ischemia- regulated gene induction in cardiac muscle in vitro and in vivo. Molecular Therapy, Vol 16, No. 9, 1594-1601 Sept 2008.

 

Billecke SS, D'Alecy LG, Platel R, Whitesall SE, Jamerson KA, Perlman RL, Gadegbeku CA. Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease.  Nephrol Dial Transplant, doi: 10.1093/ndt/gfn500, 2008.

 

Feng M, Whitesall SE, Zhang Y, Beibel M, D'Alecy LG, DiPetrillo K.  Validation of volume-pressure recording tail-cuff blood pressure measurements. Am J Hypertens, doi: 10.1038/ajh.2008.301

 

Dvonch JT, Brook RD, Keeler GJ, Rajagopalan  S, D’Alecy L.G, Marsik FJ, Morishita M, Yip FY, Brook JR, Wagner J, and Harkema JR. (2004) Effects of Concentrated Fine Ambient Particles on Rat Plasma Levels of Asymmetric Dimethylarginine.  Inhalation Toxicology, 16:473-480, 2004.

 

Zambricki  EA, D'Alecy LG.  Rat sex differences in anesthesia.  Comparative Medicine 54(1):49-53, 2004

 

Whitesall SE, Hoff JB, Vollmer AP and D'Alecy LG. Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods.   Am J Physiol Heart Circ Physiol 286:H2408-H2415, 2004. 

 

Sans MD, Lee SH, D'Alecy LG, and Williams J A. Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA. Am J Physiol Gastrointest   Liver Physiol 287(3):G667-675, 2004

 

Linder L, Weber DS, Whitesall SE, D'Alecy L.G, Webb RC.  Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition.  J Cardiovasc Pharmacol 46(4): 438-444, 2005.

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