Current Research:
Our central research focus is in understanding the molecular components and mechanisms that operate to regulate cellular secretion in physiological and pathophysiological circumstances. Within this broad interest, research is specifically focused in the areas of neuroscience (synaptic physiology, neuroendocrinology), and endocrinology (glucose homeostasis and insulin secretion, diabetes). Research projects focus on elucidating molecular mechanism that govern secretory throughput, and to defining the signaling pathways that regulate the mechanisms at the cellular, system and integrative levels. Projects are designed to be interdisciplinary, drawing on optical, molecular biological, electrophysiological, and integrative approaches. *Representative Publications:*
Representative Publications:
D’Andrea-Merrins, M., Chang, L., Lam A. D., Ernst, S. A., and Edward L. Stuenkel 2007. Munc18c Interaction with Syntaxin4 Monomers and SNARE Complex Intermediates in GLUT4 Vesicle Trafficking. J. Biol. Chem. 282(22):16553-16566.
Gladycheva SE, A. D. Lam, J. Liu, M. D'Andrea-Merrins, O. Yizhar, S. I. Lentz, U. Ashery, S. A. Ernst, and E. L. Stuenkel. 2007. Receptor-mediated regulation of tomosyn-syntaxin1A interactions in bovine adrenal chromaffin cells. J. Biol. Chem., 282(31):22887-22899.
Yizhar, O., N. Lipstein, S. E. Gladycheva, U. Matti, S. A. Ernst, J. Rettig, E. L. Stuenkel and U. Ashery. 2007. Multiple functional domains are involved in tomosyn regulation of exocytosis. J. Neurochem, 103(2):604-616
Lam, A. D., Tryoen-Toth, P., Tsai, B, Vitale, N. and E. L. Stuenkel. 2008. SNARE-Catalyzed Fusion Events are Regulated by Syntaxin1A-Lipid Interactions. Mol Biol. Cell. 19(2):485-497.
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