Current Research: 

Pancreatic growth regulation and tumorigenesis, and the role of the TGFbeta family signaling pathway; stem cells and  pancreatic cancer, and molecular profiling and biomarker discovery in pancreatic cancer.

Selected Publications:

Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson J, Giordano, TJ, Misek D, Hanash S. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res. 63: 2649-2657, 2003.

Shedden KA, Taylor JM, Giordano T, Kuick R, Misek DE, Rennert G, Schwartz, Gruber S, Logsdon C, Simeone DM, Greenson JK, Cho KR, Beer DG, Fearon ER, Hanash S. Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathologic tree-based framework. Am J Pathol 163(5): 1985-1995, 2003.

Tretalaur M, Zhang L, Simeone DM, O’Shea S, Burant C. Nestin lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes 52:2503-2512, 2003.

Arumugam T, Simeone DM, Schmidt AM, Logsdon CD. S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). J Biol Chem 279: 5059-5065, 2004.

Zhang L, Duan C, Binkley C, Uhler M, Logsdon CD, Simeone DM. A TGFb-induced Smad3/Smad4 complex directly activates Protein Kinase A. Mol Cell Biol 24: 2169-2180, 2004.

Hong SH, Misek DE, Wang H, Puravs E, Giordano TJ, Greenson JK, Brenner DE, Simeone DM, Logsdon CD, and Hanash SM. An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer. Cancer Res 2004; 64: 5504-5510.

Okami J, Simeone DM, Logsdon CD. Silencing of the hypoxia inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res 2004; 64: 5338-5346.

Arumugam T, Simeone DM, Van Golen K, Logsdon CD. S100P promotes pancreatic cancer growth, survival, and invasion. Clin Cancer Res 2005; 11: 5356-5364.

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