Faculty Profiles

Current Research:  
Our laboratory studies the cellular mechanisms that control pancreatic cell function and dysfunction. Current projects include: 1) Pancreatic cancer is the fourth leading cause of cancer deaths in the US. We are examining gene expression, using microarray technology, and protein expression, using several proteomic approaches, in order to develop biomarkers for early detection and diagnosis of pancreatic cancer as well as to discover new targets for therapy 2) Acute pancreatitis is a disease that involves pancreatic inflammation, edema, and necrosis and that can lead to cancer. we have identified several genes that are expressed early in the development of this inflammatory disease and are investigating their roles in the disease using animal models and adenoviral mediated gene delivery.

Representative Publications:
Nicke, B, M-J. Tseng, M.C. Fenrich and C.D. Logsdon. "Adenovirus-Mediated Gene Transfer of Dominant Negative Rasasn17 in Pancreatic Acinar Cells Inhibit Specific CCK Actions." Amer Jour Physiology, 276: G499-G506, 1999.

Han, B., and Logsdon, C.D. "NFkB Activation is Required for Cholecystokinin Induction of Mob-I Chemokine Gene Expression in Rat Pancreatic Acinar Cells." Am Jour Physiology, 277:C74-C82, 1999.

Nicke, B., Detjen, K.D., and Logsdon, C.D. "Muscarinic Cholinergic Receptors Activate Both Inhibitory and Stimulatory Growth Mechanisms in NIH3T3 Cells." Jour Biol Chem, 274:21701-21706, 1999.

Han, B., and C.D. Logdson. "Activation of NF-kB by Cholecystokinin Requires Protein Kinase C and Intracellular Ca2+." Amer Jour Physiology, 278: 344-351, 2000.

Baoan Ji, ALan Kopin, and Craig D. Logsdon. "CCKa Receptor Structural Differences Determine the Acinar Cell Response to the CCK Analog JMV-180 in Rat and Mouse." JBC published March 24, 2000 as 10.1074/jbc.M0016852000.

Chen, X., B. Ji, B. Han, S.A. Ernst, D. Simeone, and C.D. Logsdon. "Acute Pancreatitis and Systemic Inflammatory Response Induced by NF-kappaB Activation in Pancreas." Gastroenterology, 122(2):448-57, 2002.

Logsdon C.D., D. Simeone, T. Arumugam, C. Binkley, B. Ji, J. Greenson, T.J. Giordano, D.E. Misek, R. Kuick, S. Hanash. "Molecular Profiling of Pancreatic Adenocarcinoma and Chronic Pancreatitis Identifies Multiple Genes Differentially Regulated in Pancreatic Cancer." Cancer Res. 63(10):2649-57, 2003.

Ji, B. X-q Chen, D.E. Misek, R. Kuick, S. Ernst, R. Najarian, and C. D. Logsdon. "Pancreatic Gene Expression During the Initiation of Acute Pancreatitis: Identification of EGR-1 as a Key Regulator." Physiol Genomic,. 2003 Apr 22 [epub ahead of print]

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