Faculty Profiles

 

Current Research: 
The research in the Muscle Biology Laboratory is focused on skeletal muscle metabolism. We are especially interested in the modulation of glucose transport by exercise and calorie restriction (consuming 60% of ad libitum uptake), and how these interventions are influenced by advancing age. Each of these interventions can lead to a substantial improvement in skeletal muscle insulin sensitivity, which is a significant benefit for health. The improved insulin sensitivity after a bout of exercise facilitates the restoration of muscle glycogen stores, thereby improving the capacity for subsequent exercise. Our long-term goals are to understand the specific mechanisms whereby these physiological interventions lead to improved insulin sensitivity.

 

Selected Publications:

Arias, E.B and G.D. Cartee. “In vitro simulation of calorie restriction-induced decline in glucose and insulin leads to increased insulin-stimulated glucose transport in rat skeletal muscle.” Am. J. Physiol.(Endocrinol. Metab.). 293: E1782-E1788, 2007.

 

Arias, E.B., J. Kim, K. Funai and G.D. Cartee. “Prior exercise increases Akt Substrate of 160 kDa phosphorylation in rat skeletal muscle”. Am. J. Physiol. (Endocrinol. Metab.) 292: E1191-E1200, 2007.

 

Cartee, G.D. and J.F. Wojtaszewski. “Role of Akt Substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport”. Appl. Physiol, Nutr. Metab. 32: 557-556, 2007.

 

Kim, J., E.B. Arias and G.D. Cartee. “Effects of prior swim exercise on glucose uptake in isolated skeletal muscles from mice,” J. Physiol. Sci. 56: 305-312, 2006.

 

Hamada, T., E.B. Arias and G.D. Cartee. “Increased submaximal insulin-stimulated glucose uptake in mouse skeletal muscle after treadmill exercise.” J. Appl. Physiol. 101: 1368-1376, 2006.

 

Bruss, M.D., E.B. Arias, G.E. Lienhard, and G.D. Cartee. "Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity." Diabetes. 54: 41-50, 2005.

 

McCurdy, C.E, R.T. Davidson and G.D. Cartee. "Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle." Am. J. Physiol.(Endocrinol. Metab.). 288: E996-E1001, 2005.

 

McCurdy, C.E. and G.D. Cartee. "Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle." Diabetes. 54: 1349-1356, 2005.

 

Sancho, R., J. Kim and G.D. Cartee. "Decreased contraction-stimulated glucose transport in isolated epitrochlearis muscles of pregnant rats". J. Appl. Physiol. 98: 1021-1027, 2005.

 

Kim, J., R.S. Solis, E.B. Arias, and G.D. Cartee. "Post-contraction insulin sensitivity: Relationship with contraction protocol, glycogen concentration and 5'AMP-activated protein kinase phosphorylation". J. Appl. Physiol. 96: 575-583, 2004.

 

Arias, E.B., J. Kim, and G.D. Cartee. "Prolonged incubation in PUGNAC results in increased protein O-linked glycosylation and insulin resistance in rat skeletal muscle". Diabetes. 53: 921-930, 2004.

 

McCurdy, C.E., R.T. Davidson, and G.D. Cartee. "Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle". Am. J. Physiol.(Endocrinol. Metab.) 48: E693-E700, 2003.

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