Faculty Profiles

Research Interests: 
The Hsu laboratory studies genetics and cell biology of aging using C. elegans as a model organism. Current projects have been focused on unraveling the role of Heat-shock Factor (HSF) in specifying longevity, stress resistance, and the onset of age-related neurodegenerative diseases. Another research focus of his group is to identify genes that are responsible for the longevity response to dietary restriction. Finally, his group is also working on developing new therapeutic agents that can delay the rate of aging using the C. elegans model.

Recent Publications:
Hsu, A.-L., Feng, Z., Hsieh, M.-Y. , and Xu, X.Z.: "The Rate of Motor Activity Decline in Aging C. elegans Predicts Lifespan" Neurobiology of Aging. 2008; [Epub ahead of Print] (*These authors contributed equally)

M. Hansen*,A.-L. Hsu*, A. Dillin, and C. Kenyon (2005) “New Genes Tied to Endocrine, Metabolic and Dietary Regulation of Longevity in C. elegans.” PLOS Genetics, 1, 119-134. (* These authors contributed equally.)

A.-L. Hsu, C. Murphy, and C. Kenyon (2003) “Regulation of Aging and Age-Related Diease by DAF-16 and Heat-Shock Factor.” Science, 300, 1142-1145.

A. Dillin, A.-L. Hsu, N. Arantes-Oliveira, J. Lehrer-Graiwer, H. Hsin, A.G. Fraser, R.S. Kamath, J. Ahringer, and C. Kenyon (2002) “Rates of Behavior and Aging Specified by Mitochondrial Function During Development.” Science, 298, 2398-401 ; published online Dec. 5 2002 (10.1126/science.1077780).

D. Garigan, A.-L. Hsu, A.G. Fraser, R.S. Kamath, J. Ahringer, and C. Kenyon (2002). “Genetic Analysis of Tissue Aging in C. elegans: Heat-shock Factor Prevents Progeria and Proliferating Bacteria Kill the Animal.” Genetics, 161, 1101-1112.

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