Postdoctoral Profiles

 

Current Research: 
As an undergraduate student at the Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, I became interested in digestive exocrine secretions. I did my PhD in 2006 studying central and peripheral regulations of pancreatic secretion by C-type and atrial natriuretic peptides. The strong involvement of John Williams’ Lab in exocrine pancreas research drew me to pursue my post-doctoral in his lab. My current area of research focuses on GTP-binding proteins involved in the regulation of pancreatic amylase secretion.

 

 

Selected Publications:

Sabbatini, ME. Natriuretic peptides as regulatory mediators of secretory activity in the digestive system. Reg Pept,  2009 in press.

 

Williams, JA, Chen X, Sabbatini, ME. Small G proteins as key regulators of pancreatic digestive enzyme secretion. Am J Physiol Endocrinol Metab, 296:E405-E414, 2009.

 

Sabbatini, ME, Chen X, Ernst SA, Williams, JA. Rap1 activation plays a regulatory role in pancreatic amylase secretion. J Biol Chem, 283(35):23884-23894, 2008.

 

Sabbatini, ME, Rodríguez MR, Dabas P, Vatta MS,  Bianciotti LG. C-type natriuretic peptide stimulates pancreatic exocrine secretion in the rat: Role of vagal afferent and efferent pathways. Eur. J. Pharmacol., 577(1-3):192-202, 2007.

 

Sabbatini ME, Rodríguez MR, di Carlo MB, Davio CA, Vatta  MS,  Bianciotti LG. C-type natriuretic peptide enhances amylase release through NPR-C receptors in the exocrine pancreas. Am. J. Physiol. Gastrointest. Liver Physiol., 293: G987-G994, 2007.

 

Sabbatini ME., Vatta MS, Davio CA, Bianciotti LG. Atrial natriuretic factor negatively modulates secretin intracellular signaling in the exocrine pancreas. Am. J. Physiol. Gastrointest. Liver Physiol., 292(1):G349-G357, 2007.

 

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