Postdoctoral Profiles

 

Current Research: 
Using transgenic mouse models and cell culture system to study the roles of nuclear transcription factor PPAR-gamma in cardiovascular disease and diabetes.

 

 

Selected Publications:

Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL. In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse PDX-1 promoter. J Biol Chem. 2008 Aug 21. [Epub ahead of print]

 

Duan SZ, Ivashchenko CY, Usher MG, Mortensen RM. PPAR-g in the cardiovascular system. PPAR Res 2008: 745804.

 

Duan SZ, Usher MG, Mortensen RM. PPAR-g mediated effects in the vasculature. Circ Res 2008; 102(3): 283-294.

 

Ye CP*, Duan SZ*, Milstone DS, Mortensen RM. Go controls the hyperpolarization-activated current, If in ES cell-derived cardiocytes. (*Co-first authors) Am J Physiol Heart and Circulatory Physiol 2008; 294(2):H979-985.

 

Duan SZ, Ivashchenko CY, Whitesall SE, D’Alecy LG, Mortensen RM. Direct monitoring pressure overload predicts cardiac hypertrophy in mice. Physiological Measurement 2007; 28(11): 1329-1339)

 

Ivashchenko CY, Duan SZ, Usher MG, Mortensen RM. PPAR-g knockout in pancreatic epithelial cells abolishes the inhibitory effect of Rosiglitazone on cerulein-induced acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 2007; 293(1): G319-326.

 

Duan SZ, Christe M, Milstone DS, Mortensen RM. Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice. Biochem Biophys Res Commun 2007; 357(1): 139-143.

 

Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM. Hypotension, lipodystrophy, and insulin resistance in generalized PPAR-g-deficient mice rescued from embryonic lethality. J Clin Invest 2007; 117(3): 812-822.

 

Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-g  both induce cardiac hypertrophy in mice. Circ Res. 2005; 97(4): 372-379.

 

Back to list of postdocs