Current Research:
My research interests revolve around regulatory biology and the
physiological responses of animals to metabolic stress. In particular,
I am interested in how hormonal and nutritional changes affect cellular
protein turnover. Currently, I am studying how changes in dietary protein, as well as the hormones and neurotransmitters released in response to dietary
protein ingestion, regulate exocrine pancreas growth and secretion in
the mouse. In the future, I would like to study the mechanisms whereby conditions of metabolic stress, such as aging and pregnancy, affect nutrient
assimilation and whole-body protein turnover.
Selected Publications:
S.J. Crozier, S.R. Kimball, S.W. Emmert, J.C. Anthony, and L.S. Jefferson. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. Journal of Nutrition. 135: 376-382. 2005.
A.K. Reiter, S.J. Crozier, S.R. Kimball, and L.S. Jefferson. Meal feeding alters translational control of gene expression in rat liver. Journal of Nutrition. 135: 367-375. 2005.
S.J. Crozier, T.C. Vary, S.R. Kimball, and L.S. Jefferson. Cellular energy status modulates translational control mechanisms in ischemic-reperfused rat hearts. Am J Physiol Heart Circ. 289: 1242-50. 2005.
S.J. Crozier, M.D. Sans, L. Guo, L.G. D?Alecy, and J.A. Williams. Activation of the mTOR signaling pathway is required for pancreatic growth in protease- inhibitor-fed mice. J. Physiol. 573: 775-86. 2006.
S.J. Crozier, X. Zhang, J.F. Wang, J.Y. Cheung, S.R. Kimball, and L.S. Jefferson. Activation of Signaling Pathways and Regulatory Mechanisms of mRNA Translation Following Myocardial Ischemia/Reperfusion. J Appl Physiol. 101: 576-82. 2006.
S.J. Crozier, M.D. Sans, C.H. Lang, L.G. D?Alecy, S.A. Ernst, and J.A. Williams. CCK-induced pancreatic growth is not limited by mitogenic capacity in mice. Am J Physiol GI Liver. 294: 1148-57. 2008.
A.K. Reiter, D.R. Bolster, S.J. Crozier, S.R. Kimball, and L.S. Jefferson. AMP-activated protein kinase in liver represses translation of mRNAs bearing a terminal oligopyrimidine tract. Biochem Biophys Res Comm. (in press).
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