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Hormone Action & Signal Transduction
Larry Argetsinger, Ph.D. (University of Michigan, 1991) Mechanisms by which the cytokines which activate the tyrosine kinase Jak2 activate distinct sets of signaling pathways; mapping the phosphorylation sites in proteins.
Christin Carter-Su, Ph.D. (University of Rochester, 1978) Signalling pathways used by cytokine receptors and JAK tyrosine kinases; molecular actions of growth hormone; role of SH2-B adaptor proteins in regulation of the cytoskeleton, nerve cell differentiation and survival.
Maria Diakanova, Ph.D. (Institute of Cytology Russian Academy of Science, 1993) Implication of a novel adapter protein SH2-Bbeta in growth hormone/growth factor-dependent regulation of cellular cytoskeleton.
Gary Hammer, M.D., Ph.D. (Tufts, 1992) The molecular mechanisms of adrenal growth and differentiation, focusing on the molecular cascades involving nuclear receptors and transcriptional cofactors which initiate adrenal-specific transcriptional programs necessary for proper initiation of adrenal formation in mice and humans.
Marc B. Hershenson, M.D. (Illinois, 1981) Cellular and molecular mechanisms underlying chronic airways diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis and bronchopulmonary dysplasia.
Ormond A. MacDougald, Ph.D. (Michigan State University, 1992) Adipocyte gene expression and metabolism; transcriptional and post-translational regulation of the transcription factor C/EBPa.
Ram Menon, M.D. Understanding the role of the growth hormone (GH)/ growth hormone receptor (GHR) axis in health and disease.
Richard Mortensen, M.D., Ph.D. (Cornell, 1983, Rockefeller, 1984) Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways.
Martin Myers, M.D., Ph.D. (Harvard, 1997) Signaling pathways activated by Leptin receptor and Jak2; mechanisms of feedback inhibition of leptin receptor/Jak2 signaling; role of leptin signals in mammalian energy homeostasis, neuroendocrine function, immune function, and neuronal development.
Liangyou Rui, Ph.D. (Michigan, 1998) Cell signaling; molecular mechanisms of obesity and type 2 diabetes
Alan Saltiel, Ph.D. (North Carolina, 1980) Mechanisms of action for hormones, and growth factors; second messengers and protein phosphorylation; molecular mechanisms of diabetes.
Jessica Schwartz, Ph.D. (Harvard, 1974) Cellular and molecular mechanisms of growth factor action; regulation of gene expression.
Matthew J. Wishart, Ph.D. (University of Michigan, 2000) Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction.
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Rhythms & Reproductive Cycles
Jimo Borjigin, Ph.D. (Johns Hopkins, 1994) Molecular and cellular mechanisms of circadian clock resetting; molecular regulation of serotonin and melatonin synthesis and secretion; role of PINA (Pineal Night-specific ATPase) in circadian rythms and Wilson disease.
Fred J. Karsch, Ph.D. (Illinois, 1970) Neuroendocrine control of ovarian cyclicity, seasonal breeding, and immune-neuro-endocrine interactions.
P. Landis Keyes, Ph.D. (Illinois, 1966) Hormonal regulation of cell differentiation and steroidogenesis in the ovary. Role of immune cells in ovarian function.
Vasantha Padmanabhan, Ph.D. (Indian Insitutute of Science, 1971)
Translational and centers on understanding the fetal origin of pubertal and adult reproductive and metabolic disorders and the impact of steroids and estrogenic environmental pollutants in programming such defects
Gary Smith, Ph.D. (Washington State, 1993) Mammalian gamete and embryo developmental biology.
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Gastrointestinal Physiology
Juanita L. Merchant, M.D., Ph.D. (Yale, 1984) Molecular mechanisms of gastric epithelial cell growth.
Linda C. Samuelson, Ph.D. (Chicago, 1984) Function of gut/brain peptides in the mouse; mouse developmental genetics; generation of mouse mutants by homologous recombination in embryonic stem cells.
John A. Williams, M.D., Ph.D. (Washington (Seattle), 1968) Calcium as an intracellular messenger; cellular mechanisms of pancreatic secretion; regulation of pancreatic growth.
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Cardiovascular & Hypertension
David Bohr, M.D. (Michigan, 1942) Mechanisms responsible for hypertension.
Steven L. Britton, Ph.D. Aerobic capacity is the major determinant of the continuum between health and disease.
Louis G. D'Alecy, D.M.D., Ph.D. (Pennsylvania, 1971) Mechanisms of gender-based differences in ischemic tolerance; cardiorespiratory function in transgenic mice by telemetry techniques; adaption to acute hypoxia (high altitude); endogenous inhibitors of nitric oxide synthase in ischemia, multiorgan failure; therapeutic protection of the brain, spinal cord, and kidney.
Warren E. Lockette, M.D. (Michigan, 1981) Molecular genetics of human hypertension and diabetes mellitus; ethnic differences in acid excretion and bone mineralization; cardiovascular adaption to exercise training.
Richard Keep, Ph.D. (Aberdeen, UK, 1984) Blood-brain and blood-cerebrospinal fluid barrier physiology; brain injury following cerebral ischemia and cerebral hemorrhage; obesity and the genesis of hypertension.
Joseph M. Metzger, Ph.D. (Marquette, 1985) Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart.
Daniel E. Michele, Ph.D. (Michigan, 2000) Molecular mechanisms of human cardiomyopathies and skeletal myopathies, with a focus on muscular dystrophy, using mouse models. Extracellular matrix receptors in central nervous system development and muscle disease.
Margaret Westfall, Ph.D. (Loyola, 1989) Thin filament regulation of contractile function; cellular and molecular dissection of contractile function using viral-based gene transfer into cardiac myocytes.
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Renal Function
Frank Brosius, M.D. (Kansas, 1979) Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and metabolism in the pathogenesis of vascular changes in hypertension.
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Muscle Contractile Mechanisms
Susan V. Brooks, Ph.D. (Michigan, 1992) Single skeletal muscle fiber mechanics; role of contraction-induced muscle injury in the changes that occur in skeletal muscle structure and function with aging, and in the pathogenesis of muscular dystrophy.
John A. Faulkner, Ph.D. (Michigan, 1962) Muscle mechanics and mechanisms involved in injury, degeneration, and regeneration of skeletal muscle fibers.
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Channels & Membrane Function
Bret A. Hughes, Ph.D. (Berkeley, 1983) Structure, function, and regulation of ion channels in the retinal pigment epithelium.
Anatoli N. Lopatin, Ph.D. (Moscow, Russia, 1990) Regulation of potassium channels by polyamines.
James Offord, Ph.D. (University of Iowa, 1986) Molecular biological techniques to understand structure and function of voltage sensitive calcium channels and inward rectifier potassium channels.
Donald G. Puro, M.D., Ph.D. (Rochester, 1975) Physiology of ion channels in retinal glial and vascular cells.
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Neurophysiology
Robert Bradley, Ph.D. (Florida State, 1970) Neurophysiology of the taste system.
Kenneth L. Casey, M.D. (Washington, (Seattle), 1961) Forebrain mechanisms of pain in humans and animal models.
Ralph Lydic, Ph.D. (Texas Tech, 1979) Transmembrane cell signaling; integrative aspects of respiratory and arousal state control.
John S. McReynolds, M.D. (Harvard, 1965) Neurophysiology of the retina.
Thomas Morrow, Ph.D. (Michigan, 1976) Neurobehavioral mechanisms of pain and somatic sensation.
Goeffrey G. Murphy, Ph.D. (UCLA, 1998) Neurobiological substrates of learning and memory.
Mark Opp, Ph.D. (Washington State, 1987) Stressor-induced alterations in arousal state.
Gina Poe, Ph.D. (University of California, Los Angeles, 1995) Basic sleep processes, development, learning and memory, and optimization of cognitive performance.
Edward L. Stuenkel, Ph.D. (Hawaii, 1983) Molecular and cellular regulation of neurotransmitter and neurohormone secretion.
Michael Wang, M.D., Ph.D. (Johns Hopkins, 1994) Molecular basis or endogenous factors which improve outcome from neuronal injury with an emphasis on stroke. Two main areas of interest include: 1) signaling mechanisms within neurons triggered by estrogen, and 2) neuronal genes induced by bone morphogenetic proteins.
X.Z. Shawn Xu, Ph.D. (Johns Hopkins) 1) Neurobiology of behavior and drug addiction in the genetic model organism C. elegans. 2) Regulation of neuronal activity and fertilization by calcium signaling.
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