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Hormone Action & Signal
Transduction
Larry Argetsinger, Ph.D. (University of Michigan, 1991) Mechanisms
by which the cytokines which activate the tyrosine kinase Jak2 activate
distinct sets of signaling pathways; mapping the phosphorylation
sites in proteins.
Christin Carter-Su,
Ph.D. (University of Rochester, 1978) Signalling pathways used
by cytokine receptors and JAK tyrosine kinases; molecular actions
of growth hormone; role of SH2-B adaptor proteins in regulation
of the cytoskeleton, nerve cell differentiation and survival.
Maria
Diakanova, Ph.D. (Institute of Cytology Russian Academy of Science,
1993) Implication of a novel adapter protein SH2-Bbeta in growth
hormone/growth factor-dependent regulation of cellular cytoskeleton.
Gary
Hammer, M.D., Ph.D. (Tufts, 1992) The molecular mechanisms
of adrenal growth and differentiation, focusing on the molecular
cascades involving nuclear receptors and transcriptional cofactors
which initiate adrenal-specific transcriptional programs necessary
for proper initiation of adrenal formation in mice and humans.
Ormond A. MacDougald,
Ph.D. (Michigan State University, 1992) Adipocyte gene expression
and metabolism; transcriptional and post-translational regulation
of the transcription factor C/EBPa.
Richard Mortensen, M.D.,
Ph.D. (Cornell, 1983, Rockefeller, 1984) Molecular signal transduction
pathways important in cardiovascular risk and disease. Pathways
in hypertension and diabetes. G-proteins, PPARs, growth pathways.
Liangyou
Rui, Ph.D. (Michigan, 1998) Cell signaling; molecular mechanisms
of obesity and type 2 diabetes
Alan
Saltiel, Ph.D. (North Carolina, 1980) Mechanisms of action for
hormones, and growth factors; second messengers and protein phosphorylation;
molecular mechanisms of diabetes.
Jessica Schwartz, Ph.D.
(Harvard, 1974) Cellular and molecular mechanisms of growth factor
action; regulation of gene expression.
Matthew J. Wishart, Ph.D. (University of Michigan, 2000)
Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase
adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian
reproduction.
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Rhythms & Reproductive Cycles
Jimo Borjigin, Ph.D.
(Johns Hopkins, 1994) Molecular and cellular mechanisms of circadian
clock resetting; molecular regulation of serotonin and melatonin
synthesis and secretion; role of PINA (Pineal Night-specific ATPase)
in circadian rythms and Wilson disease.
Fred J. Karsch, Ph.D.
(Illinois, 1970) Neuroendocrine control of ovarian cyclicity, seasonal
breeding, and immune-neuro-endocrine interactions.
P. Landis Keyes, Ph.D.
(Illinois, 1966) Hormonal regulation of cell differentiation and
steroidogenesis in the ovary. Role of immune cells in ovarian function.
Gary Smith, Ph.D.
(Washington State, 1993) Mammalian gamete and embryo developmental
biology.
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Gastrointestinal
Physiology
Craig D. Logsdon, Ph.D.
(Berkeley, 1981) Molecular basis of pancreatic disease.
Juanita L. Merchant,
M.D., Ph.D. (Yale, 1984) Molecular mechanisms of gastric epithelial
cell growth.
Linda C. Samuelson, Ph.D.
(Chicago, 1984) Function of gut/brain peptides in the mouse; mouse
developmental genetics; generation of mouse mutants by homologous
recombination in embryonic stem cells.
R. Alberto Travagli,
Ph.D.(Georgetown, 1993) Cellular mechanisms underlying the central
control of gastrointestinal functions.
John A. Williams, M.D.,
Ph.D. (Washington (Seattle), 1968) Calcium as an intracellular
messenger; cellular mechanisms of pancreatic secretion; regulation
of pancreatic growth.
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Cardiovascular
& Hypertension
David Bohr, M.D. (Michigan,
1942) Mechanisms responsible for hypertension.
Louis G. D'Alecy, D.M.D.,
Ph.D. (Pennsylvania, 1971) Mechanisms of gender-based differences
in ischemic tolerance; cardiorespiratory function in transgenic
mice by telemetry techniques; adaption to acute hypoxia (high altitude);
endogenous inhibitors of nitric oxide synthase in ischemia, multiorgan
failure; therapeutic protection of the brain, spinal cord, and kidney.
Stevo Julius, M.D., ScD.
(Zagreb, Yugoslavia, 1964) Pathophysiology of arterial hypertension.
Warren E. Lockette,
M.D. (Michigan 1981) Molecular genetics of human hypertension
and diabetes mellitus; ethnic differences in acid excretion and
bone mineralization; cardiovascular adaption to exercise training.
Richard Keep, Ph.D. (Aberdeen, UK, 1984) Blood-brain and blood-cerebrospinal
fluid barrier physiology; brain injury following cerebral ischemia
and cerebral hemorrhage; obesity and the genesis of hypertension.
Joseph M. Metzger, Ph.D.
(Marquette, 1985) Viral-based gene transfer into the heart; cellular
and molecular mechanisms of contraction in skeletal and cardiac
muscle; cardiac gene expression and function; gene therapy for the
heart.
Margaret Westfall, Ph.D.
(Loyola, 1989) Thin filament regulation of contractile function;
cellular and molecular dissection of contractile function using
viral-based gene transfer into cardiac myocytes.
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Renal
Function
Frank Brosius, M.D. (Kansas,
1979) Pathways by which glucose transporter expression affects cell
death and the pathogenesis of diabetic nephropathy; abnormalities
of glucose transport and metabolism in the pathogenesis of vascular
changes in hypertension.
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Muscle
Contractile Mechanisms
Susan V. Brooks, Ph.D.
(Michigan, 1992) Single skeletal muscle fiber mechanics; role of
contraction-induced muscle injury in the changes that occur in skeletal
muscle structure and function with aging, and in the pathogenesis
of muscular dystrophy.
John A. Faulkner, Ph.D.
(Michigan, 1962) Muscle mechanics and mechanisms involved in injury,
degeneration, and regeneration of skeletal muscle fibers.
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Channels
& Membrane Function
Bret
A. Hughes, Ph.D. (Berkeley, 1983) Structure, function, and regulation
of ion channels in the retinal pigment epithelium.
Anatoli N. Lopatin,
Ph.D. (Moscow, Russia, 1990) Regulation of potassium channels
by polyamines.
James Offord, Ph.D.
(University of Iowa, 1986) Molecular biological techniques to understand
structure and function of voltage sensitive calcium channels and
inward rectifier potassium channels.
Donald
G. Puro, M.D., Ph.D. (Rochester, 1975) Physiology of ion channels
in retinal glial and vascular cells.
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Neurophysiology
Robert Bradley, Ph.D.
(Florida State, 1970) Neurophysiology of the taste system.
Kenneth L. Casey,
M.D. (Washington, (Seattle), 1961) Forebrain mechanisms of pain
in humans and animal models.
Ralph
Lydic, Ph.D. [www.umich.edu/~neurosci/faculty/lydic.htm](Texas
Tech, 1979) Transmembrane cell signaling; integrative aspects of
respiratory and arousal state control.
John S. McReynolds, M.D.
(Harvard, 1965) Neurophysiology of the retina.
Hylan C. Moises, Ph.D.
(Rochester, 1979) Cellular and molecular regulation of ion channel
function and synaptic transmission by opioid and other G-protein
coupled receptors.
Thomas Morrow,
Ph.D. (Michigan, 1976) Neurobehavioral mechanisms of pain and
somatic sensation.
Mark
Opp, Ph.D. [www.umich.edu/~neurosci/faculty/opp.htm] (Washington
State, 1987) Stressor-induced alterations in arousal state.
Gina Poe, Ph.D. (University
of California, Los Angeles, 1995) Basic sleep processes, development,
learning and memory, and optimization of cognitive performance.
Edward L. Stuenkel, Ph.D.
(Hawaii, 1983) Molecular and cellular regulation of neurotransmitter
and neurohormone secretion.
R.
Alberto Travagli, Ph.D.(Georgetown, 1993) Cellular mechanisms
underlying the central control of gastrointestinal functions.
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