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Course
Listings
Graduate
Courses
Phys 510 Systems & Integrative Physiology
Phys 541 Mammalian Reproductive Endocrinology
Phys 555 Integrative Genomics
Phys 576 Signal Transduction
Phys 577 Channels & Transporters
Phys 578 Nerve, Muscle, Synapse
Phys 591 Special Topics in Signal Transduction
Phys 606 Current Topics in Physiology
Phys 615 Techniques in Physiology Instruction
Phys 693 Cellular and Integrative Neurophysiology (Not currently offered)
Phys 699 Directed Readings
Phys 990 Dissertation/Precandidate
Phys 995 Dissertation/Candidate
Other Courses in Physiology
Phys 201 Human Physiology
Phys 502 Human Physiology
Phys 519 Quantitative Physiology (Not currently offered)
LS&A 252 Sophomore Seminar
Undergraduate Research
Phys 306 Problems in Physiology
Phys 405 Research Problems in Physiology
Graduate
Courses
Phys
510
Systems & Integrative Physiology
Fall
4cr
MWTh; 2:00 - 3:30 pm
This course addresses major principles of how the various physiological
systems of the body function, both individually and as an integrated
unit. The first part of the course deals with principles of physiological
communication as it relates to homeostasis, biological rhythms,
and both neural and endocrine communication. This is followed by
consideration of various physiological regulatory systems including
muscle, cardiovascular, respiratory, renal, gastrointestinal and
reproductive physiology. Emphasis is given not only to major principles
but also to how these principles were developed. The class format
consists of lectures, student/faculty discussions of primary research
literature, and informal discussions aimed at illustrating how individual
physiological regulatory systems are integrated to allow adaptation
to changes in the internal and external environments during everyday
life experiences and at times of stress and disease.
Course Director:
Dr. Fred Karsch, fjkarsch@umich.edu
Prerequisites: None
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Phys
541
Mammalian Reproductive Endocrinology
Winter 4cr
TTH; 2:00-4:00 pm
A study of the reproductive hormones which are responsible for the
regulation of the female and male reproductive systems. Topics include:
the properties and mechanisms of action of pituitary gonadotropic
and sex steroid hormones, the anatomy and endocrine regulation of
the ovary and testis and of the male and female reproductive tracts,
mechanisms of fertilization and implantation, contraception, and
the endocrinology of pregnancy.
Course Director:
Dr. Theresa Lee, terrilee@umich.edu
Prerequisites: None
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Phys
555
Integrative Genomics
Winter
3cr
MWF; 11:00-12:00 pm
The recent completion of the human genome opens the door to exciting
new opportunities in the biomedical sciences. Integrative Genomics
focuses on the study of functional biology in genetically engineered
animal models. An appreciation of genetic variables, including gender
and genetic background, biological variables, including organ function
and issues relating to aging, and environmental variables, including,
nutrition, exercise, stress, and pathogens is a central feature
of the class. It is the study of the inherent complexities of genes,
biology, and environment in animals that forms the unique underpinnings
of the exciting new field of Integrative Genomics. The course features
limited class size, and faculty from several different departments
in the Medical School. Unique educational features of the class
include student developed grants, oral presentations, student-led
study section evaluations of grants, and no tests.
Course Directors:
Dr. Joe Metzger,metzgerj@umich.edu
Dr. Linda Samuelson, lcsam@umich.edu
Prerequisites: Molecular genetics (HG 541) strongly recommended
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Phys
576
Signal Transduction (Cell Phys Module 1)
Winter
1cr
MWF; 10:00-11:00 am
An overview of hormone and neurotransmitter receptors as well as
the cellular effectors that are regulated by receptor activation.
Oncogene products as signal transducers and the interaction of the
known signaling pathways will be covered. The various techniques
used to study signal transduction as well as important experimental
strategies employing these techniques will also be presented. This
course is cross-listed as Bchm 576 and Pharm 576. This course is
module I of Cellular Physiology (Phys 576, 577, 578).
Course directors:
Dr. Christy Carter-Su, Dr. Kunliang Guan, Dr. Stephen Fisher
Prerequisites: None
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Phys
577
Channels & Transporters (Cell Phys Module 2)
Winter
1cr
MWF; 10:00-11:00 am
This course is designed to introduce students to the function of
membrane transport proteins that are involved in the generation
of resting membrane potentials and action potentials, intracellular
homeostasis, and epithelial nutrient and ion transport. Topics include
the properties of cell membranes, ion channels, cotransporters,
and pumps, and the regulation of intracellular pH and cell volume.
This course is module II of Cellular Physiology (Phys 576, 577,
578).
Course director:
Dr. Bret Hughes, bhughes@umich.edu
Prerequisites: None
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Phys
578
Nerve, Muscle, Synapse (Cell Phys Module 3)
Winter
1cr
MWF; 10:00-11:00 am
An overview of the molecular, cellular, and integrative properties
of membrane excitability within the context of nerve, muscle and
synaptic function. Mechanisms of sensory reception, action potential
generation and propagation, synaptic transmission, muscle cell contraction
and molecular motors will be covered. Experimental techniques and
strategies important to investigation of these areas will be presented.
Fundamental information will be accompanied by applicability to
understanding disease states. This course is module III of Cellular
Physiology (Phys 576, 577, 587).
Course Director:
Dr. Ed Stuenkel, esterm@umich.edu
Prerequisites: None
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Phys
591
Special Topics in Signal Transduction
Fall
2cr
TH; 2:00-4:00 pm
This is a literature based discussion course that will cover both
seminal discoveries in signal transduction as well as recent advances
in the field. For each topic, the instructor will provide an overview.
In addition, two to three research papers will be discussed each
week. This is an upper level graduate course. Jointly sponsored
by the Biochemistry, Physiology and Pharmacology Departments and
is cross-listed as Bchm 590 and Pharm 590.
Course Director:
Dr. Jessica Schwartz, jeschwar@umich.edu
Dr. Anne Vojtek
Prerequisites: Course work in biochemistry and signal transduction
or permission of the course director
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Phys
606
Current Topics in Physiology (Student Seminar)
Fall/Winter
1cr
M; 4:00-5:00 pm
The goal of the Student Seminar is to improve the critical thinking
and public speaking of graduate students in Physiology. This course
will provide students with the opportunity to present data, critique
the scientific literature, and develop the ability to provide constructive
criticism to their peers. Students present a critical review of
a topic from the current scientific literature or from their own
research once each term. Second year Physiology graduate students
are required to enroll, first year PIBS students interested in a
Physiology degree are invited to register or audit the course. The
Physiology Graduate Student Representatives in consultation with
the Physiology Graduate Chair coordinate the program, establish
ground-rules and organize the schedule for each term. The Seminar
is graded pass/fail on the basis of participation and presentations.
Course Director:
Dr. Fred Karsch, fjkarsch@umich.edu
Prerequisites: None
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Phys
615
Techniques in Physiology Instruction
Fall
2cr
TBA
Since teaching and effective presentations of research are vital
components of a career in Physiology, all students are given instruction
in methods of teaching. Graduate students run weekly conference
sections for an undergraduate physiology course (Phys 201) by answering
questions, explaining challenging concepts and developing and reviewing
practice exams.
Course Director:
Dr. Beth Rust, emrust@umich.edu
Prerequisites: None
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Phys
693
Cellular and Integrative Neurophysiology
Winter (Not offered, Winter 2005)
4cr
TTH; 10:00-12:00 pm
Phys 691 Cellular Neurophysiology 2cr
Phys 692 Systems Neurophysiology 2cr
The objective of this course is to examine the cellular and molecular
basis of neuronal excitability and integration within the vertebrate
nervous system. The course is divided into two independent modules,
the first (Phys 691) covers cellular and molecular aspects of nerve
cell signaling and intercellular communication, and the second module
(Phys 692) provides an integrative coverage of human nervous system
organization and function. Content of Module I will include the
basis of neuronal excitability, voltage-gated ion channels and generation
of signals, properties and interactions of simple circuits, interactions
between neurons, synaptic plasticity and regulation of intracellular
calcium. Content of Module II includes an anatomical overview of
the brain and spinal cord, sensory coding and systems organization,
reflex and voluntary motor control, sensorimotor integration, higher
cognitive functions, and learning and memory. Students may elect
to enroll in either Phys 691 (module I), Phys 692 (module II) or
both modules (Phys 693).
Course Director:
Dr. Hylan Moises, moises@umich.edu
Prerequisites: None
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Phys
699
Directed Readings
Fall/Winter
1-4cr
TBA
Student and faculty member select a topic of interest for literature
review and one-to-one discussion.
Course Directors:
Physiology Faculty
Prerequisites: None
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Phys
990
Dissertation/Precandidate
F/W/Sp/Su
1-9cr
Dissertation research by doctoral student not yet admitted as a
Candidate.
Course Director:
Faculty Mentor
Prerequisites: Dept of Physiology graduate student
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Phys
995
Dissertation/Candidate
F/W/SpSu
8cr
Dissertation research by doctoral student admitted as a Candidate.
Course Director: Faculty Mentor
Prerequisites: advancement to candidacy
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Other
Courses in Physiology
Phys
201 (formerly 101)
Human Physiology
Fall Term
M-F 1-2p
4cr
An introductory level undergraduate course that covers the basic
principles of cell physiology and the functions of the different
organ systems in humans.
Course Director:
Dr. Beth Rust, emrust@umich.edu
Prerequisites: Sophomore standing
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Phys
500
Medical Physiology
Winter
Human systems physiology. For medical students only.
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Phys
502
Human Physiology
Winter Term
4credits
MWF 12:30 pm - 2:00 pm
Basic principles of cell physiology and the functions of the different
organ systems in humans. Open to pharmacy students, other graduate students and advanced (junior or senior) undergraduates.
Course Director:
Dr. John McReynolds, jsm@umich.edu
Prerequisites: Biology 162 or equivalent
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Phys
519
Quantitative Physiology
Fall Term (Not currently offered)
MWF 9-10am
4cr
For graduate students in Bioengineering and Physiology to understand
and develop competencies in a quantitative, research oriented, systems
and control theory approach to four topic areas in physiology: a)
permeability and transport; b) electro- and neuro-physiology; c)
muscle mechanics and biomechanical behavior; and d) heart and circulation.
Course Director:
Dr. Susan Brooks, svbrooks@umich.edu
Prerequisites: none
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LS&A
252 Sophomore Seminar
History of Medicine & the Art of Humbug
Fall Term
3cr
Th 1-3 pm
This Honors seminar centers upon the evolution of modern medicine,
including early Western medical concepts and the introduction of
scientific method. In addition, attention will be directed at current
fads; acupuncture, ESP, astral projections, chiropractic, diets,
etc.
Course Director:
Dr. Richard Malvin, rlmalvin@umich.edu
Prerequisites: LS&A Honors Student
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Undergraduate
Research
Phys
306
Problems in Physiology
F/W/Sp/Su
1-4cr
Individualized physiology instruction for undergraduates. Students
work directly with a physiology faculty member. Beginning laboratory
research and/or directed readings in a focused area of study can
be arranged. This course may be elected for a total of 8 credits
Course Director: Physiology Faculty
Prerequisites: Permission of Instructor
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Phys
405
Research Problems in Physiology
F/W/Sp/Su
1-4cr
Advanced undergraduate laboratory research. Students engage in an
independent research project that is designed with a Physiology
Faculty mentor. This course may be elected for a total of 8 credits.
Course Director: Physiology Faculty
Prerequisites: Permission of Instructor
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